| Schierling, A; Dettner, K; Schmidt, J; Seifert, K: Biosynthesis of the defensive alkaloid cicindeloine in Stenus solutus beetles, Naturwissenschaften, 99, 665-669 (2012) | |
| Abstract: To protect themselves from predation and microorganismic infestation, rove beetles of the genus Stenus produce and store bioactive alkaloids like stenusine, 3-(2-methyl-1-butenyl)pyridine, and cicindeloine in their pygidial glands. The biosynthesis of stenusine and 3-(2-methyl-1-butenyl)pyridine was previously investigated in Stenus bimaculatus and Stenus similis, respectively. Both molecules follow the same biosynthetic pathway, where the N-heterocyclic ring is derived from l-lysine and the side chain from l-isoleucine. The different alkaloids are finally obtained by slight modifications of shared precursor molecules. The piperideine alkaloid cicindeloine occurs as a main compound additionally to (E)-3-(2-methyl-1-butenyl)pyridine and traces of stenusine in the pygidial gland secretion of Stenus cicindeloides and Stenus solutus. Feeding of S. solutus beetles with [D,15N]-labeled amino acids followed by GC/MS analysis techniques showed that cicindeloine is synthesized via the identical pathway and precursor molecules as the other two defensive alkaloids. |
Zu dieser Publikation gibt es weitere Dateien zum Download
Aktuelle Termine
Aktuelle Termine
| BayCEER-Kolloquium: |
|---|
| Do. 25.04.2024 aktuell Perspectives and challenges in the restoration and conservation of two isolated habitats: gypsum and cliffs |
| BayCEER Short Courses: |
| Fr. 26.04.2024 Mobile Film Making Workshop (for students of BayCEER) |
| Ökologisch-Botanischer Garten: |
| Fr. 26.04.2024 Aktion | Kräuterreich & regional: Backkunst im ÖBG (zus. mit HWK) |
| Fr. 26.04.2024 Führung | Erdbeer-Minze und Zimmerknoblauch: Gewürzkräuter |
| So. 28.04.2024 Führung | Den Sängern auf der Spur: Vogelstimmen im ÖBG (zus. mit LBV) |