Bayreuth Biology Lecture: Vortrag von Prof. Thomas Tuschl (Rockefeller University, NY)Do. 19.07.2012 (16:30)
Kontakt: Franz X. Bogner
Prof. Thomas Tuschl spricht zum Thema:
"Characterization of regulatory small RNAs and RNA-binding proteins."
Our laboratory studies how small-RNA-containing ribonucleoprotein complexes (RNPs) and RNA-binding proteins (RBPs) regulate messenger RNAs (mRNAs) in human cells. We develop experimental approaches to record small RNA expression profiles in order to assess deregulation in normal and disease conditions. We also define the targeting sites and underlying RNA recognition elements (RREs) of RBPs and RNPs and examine regulation of mRNA stability or RNA processing upon binding. The identification of posttranscriptional regulatory networks will increase our understanding of the molecular causes of disease and may lead to the rational design of new therapeutic agents.