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TZUNTIL:20150329T010000Z
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DTSTART:20121028T030000
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RDATE:20131027T030000
RDATE:20141026T030000
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DTSTAMP:20260609T132251Z
DESCRIPTION:Introduction: Human and animal diseases caused by mosquito-born
 e viruses (moboviruses) are of growing importance in many countries of Eur
 ope including Germany. Continuing eco-climatic changes and globalization c
 reate suitable conditions for the emergence of moboviruses in Germany. Up 
 to now\, four different moboviruses have been found in Germany. In 1968\, 
 Tahyna virus (TAHV) was isolated from mosquitoes that were trapped around 
 Baunach in Bavaria. TAHV is the causative agent of Valtice fever\, an infl
 uenza-like illness occurring in summer and early autumn. Therefore\, TAHV 
 is the first human pathogenic mobovirus that was isolated from mosquitoes 
 in Germany. Since these early discoveries in the late 60s of the last cent
 ury\, mobovirus surveillance in mosquitoes\, humans and animals was not pe
 rformed regularly and therefore\, longitudinal data sets are missing\, esp
 ecially from Germany. Thus\, we initiated a program that compiles and anal
 yses mobovirus and vector data collected over a number of successive years
 . This provided a solid base to determine the underlying causes of the sea
 sonal fluctuations in mobovirus activity and the relative abundance of the
  mosquito vector species. This information can be used as a basis for vect
 or control programs and might provide an early warning of the presence of 
 moboviruses in Germany.\nResults: Since 2009\, mobovirus surveillance was 
 performed mostly in south-west Germany. So far\, more than 150.000 mosquit
 oes were captured and assayed for the presence of moboviruses. In 2009\, S
 indbis virus (SINV) was isolated from Culex and Anopheles mosquitoes that 
 were exclusively trapped in the city of Weinheim\, south-west Germany. SIN
 V is the causative agent of a febrile illness in humans associated with ma
 culopapular rash and joint pain. Consequently\, a study was initiated to i
 nvestigate the medical importance of SINV in that area. Only four out of 3
 389 investigated blood donor samples were tested positive for SINV-specifi
 c-IgG antibodies and all samples from 355 patients with clinically suspect
 ed acute SINV infections were tested negative for SINV-specific antibodies
  or SINV RNA\, thus demonstrating the low medical importance of SINV in so
 uth-west Germany. In 2009\, Batai virus (BATV) was isolated from Anopheles
  maculipennis mosquitoes trapped around the village of Waghäusel. BATV may
  cause a mild illness among sheep and cattle. Thus\, 195 serum samples fro
 m cattle’s around the village of Waghäusel were investigated for BATV-spec
 ific-IgG antibodies and two samples were tested positive\, demonstrating p
 ast BATV infections. In 2010\, Usutu virus (USUV) was isolated from Culex 
 pipiens pipiens mosquitoes trapped in the city of Weinheim. Since June 201
 1\, considerable mortality in wild and captive bird species was observed i
 n south-west Germany. Consequently\, 168 dead birds were tested for the pr
 esence of USUV and USUV RNA was detected in 80 individuals from 6 species.
  Therefore\, the mortality of birds was shown to be associated with the em
 ergence of USUV. In addition\, in January 2012\, 4\,200 serum samples from
  healthy blood donors from south-west Germany were collected and analysed 
 for USUV-specific antibodies. One IgG- and IgM-positive blood donor was co
 nfirmed to have been infected by USUV. The blood donor reported no history
  of vaccination and did not have a fever during a period of three months b
 efore the blood donation. In addition\, he had not been abroad during this
  period. These findings\, taken together with the serological results corr
 oborate the hypothesis of a pauci- or asymptomatic and autochthonous USUV 
 infection of the blood donor during late summer 2011.\nConclusion: The ear
 ly discovery of USUV in mosquitoes followed by the recent epidemic proof t
 he importance and predictive value of our mosquito based monitoring progra
 m for zoonotic moboviruses. Moreover\, public health authorities\, blood t
 ransfusion services and clinicians in Germany should be aware of the risk 
 of USUV infection in humans\, especially during late summer.
DTSTART;TZID=Europe/Berlin:20130617T180000
DTEND;TZID=Europe/Berlin:20130617T190000
LOCATION:H6\, GEO
SUMMARY:PD Dr. Jonas Schmidt-Chanasit\, Bernhard Nocht Institut für Tropenm
 edizin\, Abteilung Virologie\, Hamburg (Homepage): The German Mobovirus Su
 rveillance and Mosquito Monitoring Program\, 2009 – 2012
TRANSP:TRANSPARENT
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