He holds a BSc degree from the University of Nairobi (1979), a PhD in Reproductive Biochemistry from King’s College School of Medicine and Dentistry, University of London (1984) and an MBA from the University of Nairobi (2011). He previously held the positions of Chairman, Department of Biochemistry (1992-2002), Associate Dean, Pre-Clinical Medicine (1996-2002) Dean, Faculty of Medicine (2004-2006), all at the University of Nairobi and Deputy Vice-Chancellor (Academic Affairs), Maseno University. He has held a number of appointments in professional and learned societies, among which are: President of the Federation of African Societies of Biochemistry and Molecular Biology (1996-2000), Chairman, International Council for Scientific Unions (ICSU) Regional Committee for Africa (from 2009 - 2010), Treasurer, Kenya National Academy of Sciences (from 2000 - 2011). He has supervised over 20 MSc and PhD theses and served as external examiner at several universities.
His research interest is in the area of biochemical endocrinology in which he has published more than 40 peer reviewed articles. He is a Chartered Biologist (CBiol), a member of the Institute of Biology (MIBiol) and a Fellow of the Kenya National Academy of Sciences (FKNAS). In recognition of his contributions to teaching, research and leadership, he was decorated with the Elder of Burning Spear (EBS) and the Head of State Commendation (HSC) by His Excellency, the President of the Republic of Kenya. Professor Makawiti is currently the Chair of the Board of Directors of the Children of God Relief Institute (Nyumbani), a charity organization.